Guanosine 5'-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly.
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منابع مشابه
Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils
The mechanism of eosinophil secretion was studied in guinea pig eosinophils by measuring release of hexosaminidase from cell suspensions (greater than 98% pure) permeabilized with streptolysin-O and by whole-cell patch-clamp capacitance measurements. It is shown that release of eosinophil granule components occurs by an exocytotic mechanism in which individual granules fuse with the plasma memb...
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Onion (Allium Cepa) contains high levels of flavonoids. Although there are many studies indicating the inhibitory effects of flavonoids on xanthine oxidase, there is no report on the effect of onion on this enzyme. Therefore, in the present study, the inhibitory effects of onion on xanthine oxidase are investigated. Fresh filtered juice of onion was prepared and its inhibitory effect on guine...
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An enzymatic procedure for the synthesis of adenosine 5'-O-(3-thiotriphosphate) (ATP-r-S) on a 5O-mmol scale from dihydroxyacetone, sodium thiophosphate, ADP, and phosphoenol pyruvate is described. The synthesis uses polyacrylamide gel immobilized glycerokinase coupled to a pymvate kinase catalyzed ATP cofactor regeneration system, and polyacrylamide gel immobilized triosephosphate isomerase, g...
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Human polymorphonuclear leukocytes (PMN) respond via pertussis toxin-sensitive pathways to extracellular nucleotides with an elevation in intracellular calcium ([Ca 2+ ]i) and enhancement of the O~generation induced by the chemotactic peptide N'-formyl-Met-Leu-Phe (fMLP). Binding studies with adenosine 5'-O-(3-thio[aSS]triphosphate) ([35S]ATPyS) have recently identified at least two classes of ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1984
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)90622-8